Endocrine Abstracts

To determine the effects of 25-hydroxyvitamin D (25-OHD) status on parathyroid adenoma weight, clinical, radiological and biochemical phenotype in patients with primary hyperparathyroidism (HPTP) were studied.Methods: Eighty-two patients with pHPT who underwent surgical treatment and in whom the presence of parathyroid adenoma were confirmed histopathologically were studied retrospectively. Patients were divided into 2 groups: group A patients with 25-OH...

Hemoglobin A1c (HbA1c) is used for the long-term management of patients with diabetes mellitus (DM). Hemoglobin variants other than HbA1c and e-N-lysine-glycated HbA0 may cause analytical interference in determinations of HbA1c. Hemoglobin J is an abnormal hemoglobin, an alpha globin gene variant and present in various geographic locations. Hemoglobin J (depending on its type) has different characteristics and functions. For example hemoglobin J Capetown (α2 92Gln β2...

Introduction: Jugular vein agenesis is an extremely rare condition and its prevalence is not well-established. Case reports in the medical literature are limited, emphasizing the rarity of this anatomical variation.Case Presentation: Agenesis of the jugular vein is a rare anatomical variation characterized by the congenital absence or significant underdevelopment of the jugular vein, an essential vascular structure in the venous drainage of the head and ...

Introduction: Thyroid cancer is the most common endocrine neoplasia, with papillary thyroid carcinoma (PTC) being the subtype that represents 75 - 80% of cases; with an indolent character and a 10-year survival rate greater than 90%. Vascular infiltration is very rare in this type of tumors, which usually spread through the lymphatic route. The treatment of choice continues to be surgery with adjuvant radioiodine based on the risk stratification of recurrence and radiotherapy ...

Cis-gender females are known to mount stronger humoral immune responses than cis-gender males. Little is known about the immunophenotypes of transgender individuals on gender-affirming hormonal treatment, despite growing evidence that hormones influence the immune system.Via the process of class-switch recombination (CSR), B-cell immunoglobulin isotype ‘switches’ from early IgM/IgD classes to IgG/IgA/IgE. Whilst important in infection/vaccine responses; switched isot...

Introduction: Gestational diabetes mellitus (GDM) is the metabolic disorder most frequently associated with pregnancy, presenting important maternal and fetal implications. Strict glycemic control through lifestyle measures and/or pharmacotherapy is essential to achieve adequate obstetric-perinatal results. The objective of this study is to compare baseline characteristics and perinatal results in patients diagnosed with GDM after performing oral glucose tolerance test (OGTT) ...

Objective: 6% of people with diabetes present with diabetic foot as a complication, which means greater morbidity and mortality compared to those who do not. Its diagnosis and management by multidisciplinary teams including surgeons can improve these patients’ care. The objective was to analyze the main characteristics of patients and health results obtained, as well as to evaluate the impact of PAD (peripheral artery disease) existence in patients cared for in our multid...

Adamantinomatous craniopharyngiomas (ACPs) are among the most common intracranial tumours in children and they originate from undifferentiated pituitary progenitors. Mutations in the gene encoding for β-catenin (CTNNB1), which lead to the constitutive activation of the Wnt/β-catenin signalling pathway, have been associated with ACP. These tumours can invade adjacent structures, such as the hypothalamus, which makes comp...

Adamantinomatous craniopharyngiomas (ACPs) are among the most common intracranial tumours in children and they originate from undifferentiated pituitary progenitors. Mutations in the gene encoding for β-catenin (CTNNB1), which lead to the constitutive activation of the Wnt/β-catenin signalling pathway, have been associated with ACP. These tumours can invade adjacent structures, such as the hypothalamus, which makes comp...

Introduction: Fine-needle biopsy with cytologic evaluation remains the diagnostic test of choice to distinguish benign from malignant thyroid nodules, but fails to classify thyroid nodules in 15% to 30% of cases (indeterminate thyroid nodules-ITN). ‘Rule out’ molecular testing improves the diagnostic accuracy, with high sensitivity and negative predictive value, ranging from 86 to 96%. However, these tests are not widely available, and notably increase costs. <p ...